sage decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unfamiliar. Theoretical interaction; some species of sage may perhaps bring about convulsions.

glucagon increases toxicity of scopolamine by Other (see comment). Stay away from or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the danger of gastrointestinal adverse reactions because of additive results on inhibition of gastrointestinal motility. .

Diazepam would not improve or reduce hepatic enzyme action, and won't alter the metabolism of other compounds. No proof would propose diazepam alters its possess metabolism with Continual administration.[28]

fentanyl iontophoretic transdermal procedure and scopolamine the two enhance sedation. Stay away from or Use Alternate Drug. Restrict use to people for whom substitute remedy options are inadequate

In animal experiments, showed no proof of adverse developmental effects with intravenous administration in rats; embryotoxicity was noticed in rabbits at intravenous doses manufacturing plasma stages close to one hundred occasions the degrees accomplished in human beings using transdermal process

Check Intently (one)ethinylestradiol will increase the amount or result of diazepam by Mechanism: lowering metabolism.

Observe Closely (1)istradefylline will increase the amount or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

Diazepam continues to be demonstrated to be able to substitute to the behavioral consequences of barbiturates in a primate research.[128]

This amplified chloride ion influx hyperpolarizes the neuron's membrane opportunity. Because of this, the distinction between resting possible and threshold likely is greater and firing is more unlikely. Therefore, the arousal with the cortical and limbic techniques in the central anxious method is diminished.[one]

scopolamine decreases outcomes of secretin by pharmacodynamic antagonism. Stay away from or Use Alternate Drug. Concomitant use of anticholinergic drugs may well cause a hyporesponse to stimulation tests with secretin. Discontinue anticholinergic drugs at least five fifty percent-life before administering secretin.

teduglutide improves levels of diazepam by Other (see remark). Use Warning/Check. Remark: Teduglutide could maximize absorption of concomitant PO website medicines; warning with with drugs demanding titration or Individuals which has a slender therapeutic index; dose adjustment could possibly be necessary.

tazemetostat will lower the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

diazepam boosts toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Check Intently. Scientific studies have proven that The mix of benzodiazepines and buprenorphine altered the same old ceiling impact on buprenorphine-induced respiratory despair, creating the respiratory consequences of buprenorphine appear just like those of total opioid agonists.

diazepam will raise the amount or result of finerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Keep an eye on serum potassium throughout initiation and dosage adjustment of both finererone or weak CYP3A4 inhibitors. Modify finererone dosage as necessary.